Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A
Identifieur interne : 003401 ( Main/Exploration ); précédent : 003400; suivant : 003402Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A
Auteurs : Hansong Wang [États-Unis] ; Terrilea Burnett [États-Unis] ; Suminori Kono [Japon] ; Christopher A. Haiman [États-Unis] ; Motoki Iwasaki [Japon] ; Lynne R. Wilkens [États-Unis] ; Lenora W. M. Loo [États-Unis] ; David Van Den Berg [États-Unis] ; Laurence N. Kolonel [États-Unis] ; Brian E. Henderson [États-Unis] ; Temitope O. Keku [États-Unis] ; Robert S. Sandler [États-Unis] ; Lisa B. Signorello ; William J. Blot [États-Unis] ; Polly A. Newcomb [États-Unis] ; Mala Pande [États-Unis] ; Christopher I. Amos [États-Unis] ; Dee W. West [États-Unis] ; Stéphane Bézieau [France] ; Sonja I. Berndt [États-Unis] ; Brent W. Zanke [Canada] ; Li Hsu [États-Unis] ; Noralane M. Lindor [États-Unis] ; Robert W. Haile [États-Unis] ; John L. Hopper [Australie] ; Mark A. Jenkins [Australie] ; Steven Gallinger [Canada] ; Graham Casey [États-Unis] ; Stephanie L. Stenzel [États-Unis] ; Fredrick R. Schumacher [États-Unis] ; Ulrike Peters [États-Unis] ; Stephen B. Gruber [États-Unis] ; Shoichiro Tsugane [Japon] ; Daniel O. Stram [États-Unis] ; Loïc Le Marchand [États-Unis]Source :
- Nature communications [ 2041-1723 ] ; 2014.
Abstract
The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (
Url:
DOI: 10.1038/ncomms5613
PubMed: 25105248
PubMed Central: 4180879
Affiliations:
- Australie, Canada, France, Japon, États-Unis
- Arizona, Californie, Caroline du Nord, Hawaï, Kyūshū, Maryland, New Hampshire, Pays de la Loire, Préfecture de Fukuoka, Région de Kantō, Texas, Victoria (État), Washington (État)
- Fukuoka, Melbourne, Nantes, Tokyo
- Université de Kyūshū, Université de Melbourne
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Zanke</name><affiliation wicri:level="1"><nlm:aff id="A14"> Division of Hematology, Faculty of Medicine, University of Ottawa and Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Division of Hematology, Faculty of Medicine, University of Ottawa and Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><affiliation wicri:level="2"><nlm:aff id="A8"> Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea> Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. 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Hopper</name><affiliation wicri:level="4"><nlm:aff id="A17"> Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population and Global Health, University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population and Global Health, University of Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A." last="Jenkins">Mark A. Jenkins</name><affiliation wicri:level="4"><nlm:aff id="A17"> Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population and Global Health, University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population and Global Health, University of Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation wicri:level="1"><nlm:aff id="A18"> Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Cancer Care Ontario, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Stenzel, Stephanie L" sort="Stenzel, Stephanie L" uniqKey="Stenzel S" first="Stephanie L." last="Stenzel">Stephanie L. Stenzel</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="2"><nlm:aff id="A8"> Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea> Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Tsugane, Shoichiro" sort="Tsugane, Shoichiro" uniqKey="Tsugane S" first="Shoichiro" last="Tsugane">Shoichiro Tsugane</name><affiliation wicri:level="3"><nlm:aff id="A4"> Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea> Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Marchand, Loic Le" sort="Marchand, Loic Le" uniqKey="Marchand L" first="Loïc Le" last="Marchand">Loïc Le Marchand</name><affiliation wicri:level="2"><nlm:aff id="A1"> Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea> Epidemiology Program, University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25105248</idno><idno type="pmc">4180879</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180879</idno><idno type="RBID">PMC:4180879</idno><idno type="doi">10.1038/ncomms5613</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002D88</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002D88</idno><idno type="wicri:Area/Pmc/Curation">002C38</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C38</idno><idno type="wicri:Area/Pmc/Checkpoint">001283</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001283</idno><idno type="wicri:Area/Ncbi/Merge">001D04</idno><idno type="wicri:Area/Ncbi/Curation">001D04</idno><idno type="wicri:Area/Ncbi/Checkpoint">001D04</idno><idno type="wicri:Area/Main/Merge">003413</idno><idno type="wicri:Area/Main/Curation">003401</idno><idno type="wicri:Area/Main/Exploration">003401</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in <italic>VTI1A</italic></title><author><name sortKey="Wang, Hansong" sort="Wang, Hansong" uniqKey="Wang H" first="Hansong" last="Wang">Hansong Wang</name><affiliation wicri:level="2"><nlm:aff id="A1"> Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea> Epidemiology Program, University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Burnett, Terrilea" sort="Burnett, Terrilea" uniqKey="Burnett T" first="Terrilea" last="Burnett">Terrilea Burnett</name><affiliation wicri:level="2"><nlm:aff id="A1"> Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea> Epidemiology Program, University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Kono, Suminori" sort="Kono, Suminori" uniqKey="Kono S" first="Suminori" last="Kono">Suminori Kono</name><affiliation wicri:level="4"><nlm:aff id="A2"> Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea> Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka</wicri:regionArea><orgName type="university">Université de Kyūshū</orgName><placeName><settlement type="city">Fukuoka</settlement><region type="province">Kyūshū</region><region type="prefecture">Préfecture de Fukuoka</region></placeName></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Iwasaki, Motoki" sort="Iwasaki, Motoki" uniqKey="Iwasaki M" first="Motoki" last="Iwasaki">Motoki Iwasaki</name><affiliation wicri:level="3"><nlm:aff id="A4"> Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea> Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Wilkens, Lynne R" sort="Wilkens, Lynne R" uniqKey="Wilkens L" first="Lynne R." last="Wilkens">Lynne R. Wilkens</name><affiliation wicri:level="2"><nlm:aff id="A1"> Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea> Epidemiology Program, University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Loo, Lenora W M" sort="Loo, Lenora W M" uniqKey="Loo L" first="Lenora W. M." last="Loo">Lenora W. M. Loo</name><affiliation wicri:level="2"><nlm:aff id="A1"> Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea> Epidemiology Program, University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Berg, David Van Den" sort="Berg, David Van Den" uniqKey="Berg D" first="David Van Den" last="Berg">David Van Den Berg</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><affiliation wicri:level="2"><nlm:aff id="A1"> Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea> Epidemiology Program, University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Keku, Temitope O" sort="Keku, Temitope O" uniqKey="Keku T" first="Temitope O." last="Keku">Temitope O. Keku</name><affiliation wicri:level="2"><nlm:aff id="A5"> Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea> Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Sandler, Robert S" sort="Sandler, Robert S" uniqKey="Sandler R" first="Robert S." last="Sandler">Robert S. Sandler</name><affiliation wicri:level="2"><nlm:aff id="A5"> Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea> Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Signorello, Lisa B" sort="Signorello, Lisa B" uniqKey="Signorello L" first="Lisa B." last="Signorello">Lisa B. Signorello</name><affiliation><nlm:aff id="A6"> Department of Epidemiology, Harvard School of Public Health, and the Channing Division of Network Medicine, Harvard Medical School, Boston, MA and Dana-Farber/Harvard Cancer Center, Boston, MA.</nlm:aff><wicri:noCountry code="subfield">MA.</wicri:noCountry></affiliation></author><author><name sortKey="Blot, William J" sort="Blot, William J" uniqKey="Blot W" first="William J." last="Blot">William J. Blot</name><affiliation wicri:level="2"><nlm:aff id="A7"> Division of Epidemiology, Vanderbilt University Medical Center/Vanderbilt-Ingram Cancer Center, Nashville, TN and International Epidemiology Institute, Rockville, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Division of Epidemiology, Vanderbilt University Medical Center/Vanderbilt-Ingram Cancer Center, Nashville, TN and International Epidemiology Institute, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation wicri:level="2"><nlm:aff id="A8"> Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea> Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Pande, Mala" sort="Pande, Mala" uniqKey="Pande M" first="Mala" last="Pande">Mala Pande</name><affiliation wicri:level="2"><nlm:aff id="A9"> Department of Gastroenterolgy - Research, the University of Texas M. D. Anderson Cancer Center, Houston, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea> Department of Gastroenterolgy - Research, the University of Texas M. D. Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name><affiliation wicri:level="2"><nlm:aff id="A10"> Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, NH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Hampshire</region></placeName><wicri:cityArea> Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon</wicri:cityArea></affiliation></author><author><name sortKey="West, Dee W" sort="West, Dee W" uniqKey="West D" first="Dee W." last="West">Dee W. West</name><affiliation wicri:level="2"><nlm:aff id="A11"> Cancer Prevention Institute of California, Fremont, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea> Cancer Prevention Institute of California, Fremont</wicri:cityArea></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bézieau">Stéphane Bézieau</name><affiliation wicri:level="3"><nlm:aff id="A12"> Service de Génétique Médicale, CHU Nantes, Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Service de Génétique Médicale, CHU Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="2"><nlm:aff id="A13"> Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea> Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W." last="Zanke">Brent W. Zanke</name><affiliation wicri:level="1"><nlm:aff id="A14"> Division of Hematology, Faculty of Medicine, University of Ottawa and Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Division of Hematology, Faculty of Medicine, University of Ottawa and Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><affiliation wicri:level="2"><nlm:aff id="A8"> Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea> Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name><affiliation wicri:level="2"><nlm:aff id="A15"> Department of Health Science Research, Mayo Clinic Arizona, Scottsdale, AZ</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea> Department of Health Science Research, Mayo Clinic Arizona, Scottsdale</wicri:cityArea></affiliation></author><author><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W." last="Haile">Robert W. Haile</name><affiliation wicri:level="2"><nlm:aff id="A16"> Stanford Cancer Institute, Stanford, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea> Stanford Cancer Institute, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="A17"> Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population and Global Health, University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population and Global Health, University of Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A." last="Jenkins">Mark A. Jenkins</name><affiliation wicri:level="4"><nlm:aff id="A17"> Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population and Global Health, University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population and Global Health, University of Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation wicri:level="1"><nlm:aff id="A18"> Cancer Care Ontario, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Cancer Care Ontario, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Stenzel, Stephanie L" sort="Stenzel, Stephanie L" uniqKey="Stenzel S" first="Stephanie L." last="Stenzel">Stephanie L. Stenzel</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="2"><nlm:aff id="A8"> Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea> Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Tsugane, Shoichiro" sort="Tsugane, Shoichiro" uniqKey="Tsugane S" first="Shoichiro" last="Tsugane">Shoichiro Tsugane</name><affiliation wicri:level="3"><nlm:aff id="A4"> Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea> Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Marchand, Loic Le" sort="Marchand, Loic Le" uniqKey="Marchand L" first="Loïc Le" last="Marchand">Loïc Le Marchand</name><affiliation wicri:level="2"><nlm:aff id="A1"> Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea> Epidemiology Program, University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author></analytic><series><title level="j">Nature communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (<italic>P</italic> < 5×10<sup>−8</sup>) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to <italic>VTI1A</italic>; <italic>P</italic>=1.4×10<sup>−9</sup>), providing additional insight into the etiology of CRC and highlighting the value of association mapping in diverse populations.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lichtenstein, P" uniqKey="Lichtenstein P">P Lichtenstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Browning, Sr" uniqKey="Browning S">SR Browning</name></author><author><name sortKey="Browning, Bl" uniqKey="Browning B">BL Browning</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Devlin, B" uniqKey="Devlin B">B Devlin</name></author><author><name sortKey="Roeder, K" uniqKey="Roeder K">K Roeder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bose, A" uniqKey="Bose A">A Bose</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kunwar, Aj" uniqKey="Kunwar A">AJ Kunwar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramirez, Dm" uniqKey="Ramirez D">DM Ramirez</name></author><author><name sortKey="Khvotchev, M" uniqKey="Khvotchev M">M Khvotchev</name></author><author><name sortKey="Trauterman, B" uniqKey="Trauterman B">B Trauterman</name></author><author><name sortKey="Kavalali, Et" uniqKey="Kavalali E">ET Kavalali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lan, Q" uniqKey="Lan Q">Q Lan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bass, Aj" uniqKey="Bass A">AJ Bass</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Loo, Lw" uniqKey="Loo L">LW Loo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pruim, Rj" uniqKey="Pruim R">RJ Pruim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, I" uniqKey="Cheng I">I Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siddiq, A" uniqKey="Siddiq A">A Siddiq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Price, Al" uniqKey="Price A">AL Price</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sankararaman, S" uniqKey="Sankararaman S">S Sankararaman</name></author><author><name sortKey="Sridhar, S" uniqKey="Sridhar S">S Sridhar</name></author><author><name sortKey="Kimmel, G" uniqKey="Kimmel G">G Kimmel</name></author><author><name sortKey="Halperin, E" uniqKey="Halperin E">E Halperin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Howie, Bn" uniqKey="Howie B">BN Howie</name></author><author><name sortKey="Donnelly, P" uniqKey="Donnelly P">P Donnelly</name></author><author><name sortKey="Marchini, J" uniqKey="Marchini J">J Marchini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peters, U" uniqKey="Peters U">U Peters</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peters, U" uniqKey="Peters U">U Peters</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zanke, Bw" uniqKey="Zanke B">BW Zanke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Willer, Cj" uniqKey="Willer C">CJ Willer</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Abecasis, Gr" uniqKey="Abecasis G">GR Abecasis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Higgins, Jp" uniqKey="Higgins J">JP Higgins</name></author><author><name sortKey="Thompson, Sg" uniqKey="Thompson S">SG Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yeager, M" uniqKey="Yeager M">M Yeager</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amundadottir, L" uniqKey="Amundadottir L">L Amundadottir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petersen, Gm" uniqKey="Petersen G">GM Petersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Landi, Mt" uniqKey="Landi M">MT Landi</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>France</li><li>Japon</li><li>États-Unis</li></country><region><li>Arizona</li><li>Californie</li><li>Caroline du Nord</li><li>Hawaï</li><li>Kyūshū</li><li>Maryland</li><li>New Hampshire</li><li>Pays de la Loire</li><li>Préfecture de Fukuoka</li><li>Région de Kantō</li><li>Texas</li><li>Victoria (État)</li><li>Washington (État)</li></region><settlement><li>Fukuoka</li><li>Melbourne</li><li>Nantes</li><li>Tokyo</li></settlement><orgName><li>Université de Kyūshū</li><li>Université de Melbourne</li></orgName></list><tree><noCountry><name sortKey="Signorello, Lisa B" sort="Signorello, Lisa B" uniqKey="Signorello L" first="Lisa B." last="Signorello">Lisa B. Signorello</name></noCountry><country name="États-Unis"><region name="Hawaï"><name sortKey="Wang, Hansong" sort="Wang, Hansong" uniqKey="Wang H" first="Hansong" last="Wang">Hansong Wang</name></region><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name><name sortKey="Berg, David Van Den" sort="Berg, David Van Den" uniqKey="Berg D" first="David Van Den" last="Berg">David Van Den Berg</name><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I." last="Berndt">Sonja I. Berndt</name><name sortKey="Blot, William J" sort="Blot, William J" uniqKey="Blot W" first="William J." last="Blot">William J. Blot</name><name sortKey="Burnett, Terrilea" sort="Burnett, Terrilea" uniqKey="Burnett T" first="Terrilea" last="Burnett">Terrilea Burnett</name><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W." last="Haile">Robert W. Haile</name><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><name sortKey="Keku, Temitope O" sort="Keku, Temitope O" uniqKey="Keku T" first="Temitope O." last="Keku">Temitope O. Keku</name><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N." last="Kolonel">Laurence N. Kolonel</name><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name><name sortKey="Loo, Lenora W M" sort="Loo, Lenora W M" uniqKey="Loo L" first="Lenora W. M." last="Loo">Lenora W. M. Loo</name><name sortKey="Marchand, Loic Le" sort="Marchand, Loic Le" uniqKey="Marchand L" first="Loïc Le" last="Marchand">Loïc Le Marchand</name><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><name sortKey="Pande, Mala" sort="Pande, Mala" uniqKey="Pande M" first="Mala" last="Pande">Mala Pande</name><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><name sortKey="Sandler, Robert S" sort="Sandler, Robert S" uniqKey="Sandler R" first="Robert S." last="Sandler">Robert S. Sandler</name><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name><name sortKey="Stenzel, Stephanie L" sort="Stenzel, Stephanie L" uniqKey="Stenzel S" first="Stephanie L." last="Stenzel">Stephanie L. Stenzel</name><name sortKey="Stram, Daniel O" sort="Stram, Daniel O" uniqKey="Stram D" first="Daniel O." last="Stram">Daniel O. Stram</name><name sortKey="West, Dee W" sort="West, Dee W" uniqKey="West D" first="Dee W." last="West">Dee W. West</name><name sortKey="Wilkens, Lynne R" sort="Wilkens, Lynne R" uniqKey="Wilkens L" first="Lynne R." last="Wilkens">Lynne R. Wilkens</name></country><country name="Japon"><region name="Kyūshū"><name sortKey="Kono, Suminori" sort="Kono, Suminori" uniqKey="Kono S" first="Suminori" last="Kono">Suminori Kono</name></region><name sortKey="Iwasaki, Motoki" sort="Iwasaki, Motoki" uniqKey="Iwasaki M" first="Motoki" last="Iwasaki">Motoki Iwasaki</name><name sortKey="Tsugane, Shoichiro" sort="Tsugane, Shoichiro" uniqKey="Tsugane S" first="Shoichiro" last="Tsugane">Shoichiro Tsugane</name></country><country name="France"><region name="Pays de la Loire"><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bézieau">Stéphane Bézieau</name></region></country><country name="Canada"><noRegion><name sortKey="Zanke, Brent W" sort="Zanke, Brent W" uniqKey="Zanke B" first="Brent W." last="Zanke">Brent W. Zanke</name></noRegion><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name></region><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A." last="Jenkins">Mark A. Jenkins</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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